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Who should read the report:
This report is intended for anyone interested in advancements in neuroscience, and anyone attending Neuroscience 2012, the Society for Neuroscience’s annual conference.
About this report:
This report highlights 11 papers that represent some of the latest discoveries in the field of neuroscience. Further, each paper is authored by one of the speakers of the Special Lectures at Neuroscience 2012. We chose the paper for its relevance to the topic of the special lecture. To further explore the topic within the neuroscience discipline, we provide two sets of related papers. One set is based on consumption (reading habits of millions of users) and the other set is based on other research the author has published. Our goal is to provide a collection of research papers that represent some of the most exciting new developments in the field of neuroscience.
About the selection and process:
We used the Neuroscience 2012 Special Lectures’ topics and authors as an indicator of interesting and influential research in neuroscience. There are 11 speakers presenting special lectures, across 7 different themes. Our report is organized by author and highlights a recent paper they’ve published on a topic similar to their special lecture topic. Each highlighted paper references the special lecture title and theme. The paper’s title hyperlinks to the paper, via pubget.com. In addition to identifying interesting and influential neuroscience papers, we wanted to identify related papers. We did that in two ways. First, we used data provided via Thomson Reuters Web of Science® to predict related papers based on reading habits. These papers are hyperlinked via pubget.com. Then we used Pubget’s author database to identify other papers that the author has published. These papers are also hyperlinked via pubget.com.
1. Author: Yves-Alain Barde, MD
Special Lecture: Neurotrophin Signaling: A New Perspective
Special Lecture Theme: Development
Related Paper:
Save or kill - the ambivalence of neurotrophin receptors.
Vincent V Bischoff, Vassiliki V Nikoletopoulou and Yves-Alain YA Barde
No abstract.
Med Sci (Paris) 27(2):119-21 (2011) PMID 21382315
Other papers by Yves-Alain Barde, MD
2. Author: Gina Turrigiano, PhD
Special Lecture: The Self-Tuning Neuron: Keeping Your Brain in Balance
Special Lecture Theme: Neural Excitability, Synapses, and Glia: Cellular Mechanisms
Related Paper:
Homeostatic synaptic plasticity: local and global mechanisms for stabilizing neuronal function.
Gina G Turrigiano
Neural circuits must maintain stable function in the face of many plastic challenges, including changes in synapse number and strength, during learning and development.
Cold Spring Harb Perspect Biol 4(1):a005736 (2012) PMID 22086977
Other papers by Gina G Turrigiano
3. Author: David D Julius, PhD
Special Lecture: From Peppers to Peppermints: Molecular Insights into Nociception and Pain
Special Lecture Theme: Neural Excitability, Synapses, and Glia: Cellular Mechanisms
Related Paper:
Signaling by sensory receptors.
David D Julius and Jeremy J Nathans.
Sensory systems detect small molecules, mechanical perturbations, or radiation via the activation of receptor proteins and downstream signaling cascades in specialized sensory cells.
Cold Spring Harb Perspect Biol 4(1):a005991 (2012) PMID 22110046
Other papers by David Julius, PhD
4. Author: Lennart Mucke, MD
Special Lecture: Alzheimer Mechanisms and Therapeutic Strategies
Special Lecture Theme: Disorders of the Nervous System
Related Paper:
Alzheimer mechanisms and therapeutic strategies.
Yadong Y Huang and Lennart L Mucke.
There are still no effective treatments to prevent, halt, or reverse Alzheimer’s disease, but research advances over the past three decades could change this gloomy picture. Genetic studies demonstrate that the disease has multiple causes.
Cell 148(6):1204-22 (2012) PMID 22424230
Other papers by Lennart Mucke, MD
5. Author: Antonello Bonci, MD
Special Lecture: Synaptic Plasticity and Substance Use Disorders: New Insights from Optogenetic Studies
Special Lecture Theme: Disorders of the Nervous System
Related Paper:
Getting to the core of addiction: Hooking CB2 receptor into drug abuse?
Marisela M Morales and Antonello A Bonci.
No abstract.
Nat Med 18(4):504-5 (2012) PMID 22481411
Other papers by Antonello Bonci, MD
6. Author: Donata Oertel
Special Lecture:Handling of Acoustic Information by the Cochlear Nuclear Complex
Special Lecture Theme:Sensory and Motor Systems
Related Paper:
Matthew J MJ McGinley, M Charles MC Liberman, … Donata D Oertel.
We test the hypothesis that the topographic arrangement of synaptic inputs on dendrites of octopus cells allows octopus cells to compensate the traveling wave delay. We show that in mice the full cochlear traveling wave delay is 1.6 ms.
J Neurosci 32(27):9301-11 (2012) PMID 22764237
Other papers by Donata Oertel, PhD
7. Author: Nikos K Logothetis, PhD
Special Lecture:Large-Scale Brain Networks: Principles and Emerging Methodologies.
Special Lecture Theme:Sensory and Motor Systems
Related Paper:
Nikos K Logothetis.
The brain can be envisaged as a complex adaptive system. It is characterized by a very high structural complexity and by massive connectivity, both of which change and evolve in response to experience.
Neuroimage (2012) PMID 22248575
Other papers by Nikos K Logothetis, PhD
8. Author: Melissa Hines, PhD
Special Lecture: Sexual Differentiation of Human Brain and Behavior
Special Lecture Theme:Integrative Systems: Neuroendocrinology, Neuroimmunology and Homeostatic Challenge
Related Paper:
Melissa M Hines.
Both sexual orientation and sex-typical childhood behaviors, such as toy, playmate and activity preferences, show substantial sex differences, as well as substantial variability within each sex.
Front Neuroendocrinol 32(2):170-82 2011 PMID 21333673
Other papers by Melissa M Hines, PhD
9. Author: Christian Lüscher, MD
Special Lecture: Drug-Evoked Synaptic Plasticity: A Key to Addiction?
Special Lecture Theme: Cognition and Behavior
Related paper:
Camilla C Bellone and Christian C Lüscher.
We review the experimental evidence for this hypothesis and discuss the implications for circuit function.
Front Mol Neurosci 5():75 (2012) PMID 22715323
Other papers by Christian Lüscher, MD
10. Author: Amy F. Arnsten, PhD
Special Lecture: Going to Hell in a Handbasket: Molecular Weakening of Prefrontal Cortical Regulation During Stress
Special Lecture Theme: Cognition and Behavior
Related paper:
Stress signaling pathways that impair prefrontal cortex structure and function.
Amy F T AF Arnsten.
The prefrontal cortex (PFC) - the most evolved brain region - subserves our highest-order cognitive abilities. However, it is also the brain region that is most sensitive to the detrimental effects of stress exposure.
Nat Rev Neurosci 10(6):410-22 1 Jun 2009 PMID 19455173
Other papers by Amy F. Arnsten, PhD
11. Author: Xiaowei Zhuang, PhD
Special Lecture: Super-Resolution Fluorescence Microscopy and Applications to Neuroscience
Special Lecture Theme: Novel Methods and Technology Development
Related paper:
Statistical deconvolution for superresolution fluorescence microscopy.
Eran A EA Mukamel, Hazen H Babcock and Xiaowei X Zhuang.
We present a computational method, referred to as deconvolution-STORM (deconSTORM), which uses iterative image deconvolution in place of single- or multiemitter localization to estimate the sample.
Biophys J 102(10):2391-400 (2012) PMID 22677393
Other papers by Xiaowei Zhuang, PhD
Most popular papers may indicate shift in scientific research to social issues such as weight control, gender differences and ADHD
What we found: Socially important issues (think any science headline news) are well represented among the most popular papers. These commonly discussed issues, like weight loss, stress, gender differences and ADHD, were all counted among the most popular papers.
Purpose: With half of 2012 behind us, we set out to curate the most popular papers of 2012 (so far) as read on Pubget.com- the search engine for life science PDFs. With this study we’re able to summarize the interest areas of the millions of scientists who use Pubget.com to find the papers they need to advance their research.
Methodology: Pubget is uniquely positioned to represent the popularity of papers, with a broad index and millions of papers viewed every month. Additionally, Pubget receives traffic from a variety of sources, including Google searches, direct visitors and visitors from referring sites, such as CiteULike, Research Blogging and university websites. This mix of traffic provides a suitably random sample of information.
Results: While the primary focus of our index is on the discovery of papers from across biomedicine (e.g., paper results you’d find in PubMed), the Pubget index is broader and includes publishers in other fields. As such, 25 of the top 30 papers are biomedical related research. Another four papers represent the physical sciences and engineering fields. And one result includes a paper from a popular news magazine.
We noticed a few key trends for this collection of papers.
Additionally, while about one third of papers were published in 2012, we were surprised by the amount of popular papers published prior to this year. However, this need for researchers to continue reading (relatively) older papers does support the common premise that the scientific community “stands on the shoulders of giants.”
Keep reading for the Top 30. The titles are clickable, and will open the paper through Pubget. If you have a subscription through your workplace, you’ll get the full text. Otherwise, you’ll see the metadata and abstract information, with links to the publisher’s website.
The Top 30 Papers read on Pubget.com
Barbara Buddeberg-Fischer, Martina Stamm and… Richard Klaghofer
Female physicians, especially those with children, have lower rates of employment and show lower values in terms of career success and career support experiences than male physicians.
BMC Health Serv Res 10(1):40 (2010) PMID 20167075
WM McDonald, Valerie Durkalski and… Mark S George
The objective was to assess the efficacy of increasing the number of fast left repetitive transcranial magnetic stimulations (rTMS) (10 Hz @ 120% of motor threshold (MT) over the left dorsolateral prefrontal cortex (DLPFC)) needed to achieve remission in treatment-resistant depression (TRD).
Depress Anxiety 28(11):973-80 (2011) PMID 21898711
Wendy Middlemiss, Douglas A Granger and… Laura Nathans
This study examines change in the synchrony between mothers’ and infants’ physiology as 25 infants (11 males; 4 to 10months of age) participate in a 5-day inpatient sleep training program in which they learn to self-settle through extinction of crying responses during the transition to sleep.
Early Hum Dev 88(4):227-32 (2011) PMID 21945361
Bryan Paton, Jakob Hohwy, and Peter G Enticott
Autism spectrum disorder (ASD) is characterized by differences in unimodal and multimodal sensory and proprioceptive processing, with complex biases towards local over global processing. Many of these elements are implicated in versions of the rubber hand illusion (RHI), which were therefore studied in high-functioning individuals with ASD and a typically developing control group.
J Autism Dev Disord [Epub ahead of print] (2011) PMID 22189963
Ming Shan, Xiaoyi Yuan and… Farrah Kheradmand
We have shown that CD1a(+) antigen-presenting cells (APCs) from lungs of patients with emphysema can induce autoreactive T helper 1 (T(H)1) and T(H)17 cells.
Sci Transl Med 4(117):117ra9 (2012) PMID 22261033
6. Executive functioning in high-IQ adults with ADHD.
KM Antshel, SV Faraone and… J J Biederman
The objective was to examine the association between psychological tests of executive functioning and functional outcomes among high-IQ adults with attention deficit hyperactivity disorder (ADHD).
Psychol Med 40(11):1909-18 (2010) PMID 20085666
7. Adaptive All-Pass Filter Achieving Low Peak-to-Average Power Ratio for OFDM Systems.
Eonpyo Hong and Dongsoo Har
This paper introduces a peak-to-average power ratio (PAPR) reduction scheme adopting a single high-order adaptive all-pass filter (AAPF
IEEE Trans Veh Tech 60(1):4029-4034 (2011) DOI: 10.1109/TVT.2011.2167766 
8. Absence of adipose triglyceride lipase protects from hepatic ER stress.
Claudia Fuchs, Thierry Claudel and… Michael Trauner
We hypothesized that absence of adipose triglyceride lipase (ATGL/PNPLA2) - the main enzyme for intracellular lipolysis, releasing FAs and closest homologue to adiponutrin (PNPLA3) recently implicated in the pathogenesis of NAFLD - protects against hepatic ER stress.
Hepatology 56(1):270-80 (2012) PMID 22271167
9. Novel TaPO5−xN2x/3 oxynitrides.
Erwan Ray, Franck Tessier and… Bruno Bureau
A series of novel nitrided tantalophosphates has been prepared by nitridation of X-ray amorphous TaPO5precursors under ammonia flow.
J Alloys Compd 513:530-538 (2012)
10. The neural substrates associated with inattentional blindness.
Preston Thakral
Whereas the behavioral manifestation of inattentional blindness has been investigated, the neural basis of this phenomenon has remained elusive. In the current study, event-related fMRI was used to identify the neural substrates associated with inattentional blindness.
Conscious Cogn 20(4):1768-75 (2011) PMID 21481608
11. The unfolding story of a redox chaperone.
MP Mayer
Oxidative stress, especially in combination with heat stress, poses a life-threatening challenge to many organisms by causing protein misfolding and aggregation.
Cell 148(5):843-4 (2012) PMID 22385952
Muhammad Amer and Rehan Qayyum
The inverse relation between vitamin D supplementation and inflammatory biomarkers among asymptomatic adults is not settled. We hypothesized that the inverse relation is present only at lower levels and disappears at higher serum levels of vitamin D.
Am J Cardiol 109(2):226-230 (2011) PMID 21996139
13. Efficacy of Low-Level Laser Therapy for Body Contouring and Spot Fat Reduction.
Mary K Caruso-Davis, Thomas S Guillot and… Frank L Greenway
Low-level laser therapy (LLLT) is commonly used in medical applications, but scientific studies of its efficacy and the mechanism by which it causes loss of fat from fat cells for body contouring are lacking. This study examined the effectiveness and mechanism by which 635–680 nm LLLT acts as a non-invasive body contouring intervention method.
Obes Surg 21(6):722-729 (2011) PMID 20393809
B S Metcalf, J Hosking and… T J Wilkin
The objective was to establish in children whether inactivity is the cause of fatness or fatness the cause of inactivity. We designed a non-intervention prospective cohort study examining children annually from 7 to 10 years.
Arch Dis Child 96(10):942-947 (2011) PMID 20573741
N Urushihara, H Fukuzawa and… H Miyake
In this article, we present our experiences with totally laparoscopic surgery comprising excision of the extrahepatic bile duct, Roux-en-Y jejunojejunostomy, and wide hepaticojejunostomy combined with hilar ductoplasty for choledochal cyst.
J Laparoendosc Adv Surg Tech A 21(4):361-6 (2011) PMID 21486149
16. The upside of being an introvert (and why extroverts are overrated).
Bryan Walsh
By some estimates, 30% of all people fall on the introvert end of the temperament spectrum, introverted does not have to mean shy, though there is overlap. Shy people actively seek to avoid social situations, even ones they might want to take part in, because they may be inhibited by fear. Introverts shun social situations because, they simply want to be alone.
Time 179(5):40-5 (2012) PMID 22355877
17. Tumor heterogeneity: mechanisms and bases for a reliable application of molecular marker design.
Salvador J Diaz-Cano
Tumor heterogeneity is a confusing finding in the assessment of neoplasms, potentially resulting in inaccurate diagnostic, prognostic and predictive tests. This tumor heterogeneity is not always a random and unpredictable phenomenon, whose knowledge helps designing better tests.
Int J Mol Sci 13(2):1951-2011 (2012) PMID 22408433
18. Program and abstracts for the 2011 Meeting of the Society for Glycobiology.
M Tony Hollingsworth, Gerald W Hart and… Carlito B Lebrilla,
We have detected the MUC1CT at promoters of over 500 genes, in association with several different transcription factors, and have shown that promoter occupancy can vary under different growth factor conditions.
Glycobiology 21(11):1454-531 (2011) PMID 21994331
19. DEER distance measurements on proteins.
Gunnar G Jeschke
Distance distributions between paramagnetic centers in the range of 1.8 to 6 nm in membrane proteins and up to 10 nm in deuterated soluble proteins can be measured by the DEER technique.
Annu Rev Phys Chem 63:419-46 (2012) PMID 22404592
20. Fifty years after Jacob and Monod: what are the unanswered questions in molecular biology?
Marc W MW Kirschner, Lucy L Shapiro and… Uri U Alon
Tomorrow’s molecular biologists might wish to look to their predecessors, take risks, and defy convention.
Mol Cell 42(4):403-4 (2011) PMID 21748867
21. Round-bale feeder design affects hay waste and economics during horse feeding.
Krishona Martinson, Julia Wilson and… Marcia Hathaway,
The objectives were to compare hay waste, hay intake, and payback of 9 round-bale feeders and a no-feeder control when used during horse feeding.
J Anim Sci 90(3):1047-55 (2011) PMID 21984721
22. Eye tracking based driver fatigue monitoring and warning system.
Hardeep Singh, J S Bhatia, and Jasbir Kaur,
The main idea behind this project is to develop a non-intrusive system which can detect fatigue of the driver and issue a timely warning.
Power Electronics IICPE (2011) DOI: 10.1109/IICPE.2011.5728062
M L Neuhouser, Y Schwarz and… J W Lampe
We conducted a randomized, cross-over feeding study testing low- compared to High-GL diets on biomarkers of inflammation and adiposity in healthy adults.
J Nutr 142(2):369-374 (2012) PMID 22190020
24.Diagnostic and interventional sialendoscopy: A preliminary experience.
MA Bowen, M Tauzin, EA Kluka and… RR Walvekar
To review our preliminary experience with diagnostic and therapeutic sialendoscopy for the management of non-neoplastic disorders of the salivary gland.
Laryngoscope 121(2):299 (2011) PMID 21271577
25. Differences between tight and loose cultures: a 33-nation study. Michele J Gelfand, Jana L Raver and… Susumu Yamaguchi
We illustrate the differences between cultures that are tight (have many strong norms and a low tolerance of deviant behavior) versus loose (have weak social norms and a high tolerance of deviant behavior).
Science 332(6033):1100-4 (2011) PMID 21617077
Girishanthy Krishnarajah, Elizabeth J Davis and… Ami R Buikema
Our objective was to compare rotavirus vaccine series completion and dosing schedule compliance between cohorts of infants who received these vaccines.
Vaccine 30(24):3717-22 (2012) PMID 22214886
Andreas L Szentivanyi, Holger Zernetsch and… Birgit Glasmacher
It is thus the goal of this review to describe the current state of electrospinning process technology with respect to the design of artificial tissue structures.
Int J Artif Organs 34(10):986-97 (2011) PMID 22161282
28. Pedagogical approach to design an e-learning courseware.
Mohamed Hussain Thowfeek and Azizah Jaafar,
This paper tries to explain the importance of amalgamating the pedagogical approaches and e-learning standards in order to develop an appropriate e-learning courseware.
Pattern Analysis and Intelligent Robotics ICPAIR 2:207-210 (2011) DOI: 10.1109/ICPAIR.2011.5976927
29. Neuroscience: In their nurture
Lizzie Buchen
Can epigenetics underlie the enduring effects of a mother’s love?
Nature 467(7312):146-148 (2010) PMID 20829771
Angela D Liese and… Desmond E Williams
Our goal was to estimate the prevalence of diabetes mellitus in youth <20 years of age in 2001 in the United States, according to age, gender, race/ethnicity, and diabetes type.
Pediatrics 118(4):1510-8 (2006) PMID 17015542
via EPOD
As NASA’s Goddard Space Flight Center looks to the stars, dinosaur tracker (how cool does that job sound) Ray Stanford and JHU expert David Weishampel discovered and confirmed (respectively) an intact footprint of a Nodosaur, which roamed the earth about 110 million years ago.
[video]
Researchers: Sound familiar? #whatshouldwecallgradschool
A stunningly powerful photo captured by NASA’s Terra satellite (via National Geographic) shows an approximately 50 mile iceberg breaking from Greenland. Icebergs breaking and melting has been scientifically documented for a while now. But did you know that studies have also documented that these free-drifting icebergs can be- at least in southern waters- a source of Iron. Intrigued? Check out this paper, this paper or this paper.
So does that mean that the next time we feel a little anemic we could jaunt over to Antartica for some iron-enriched ocean water?
Want to know what the global science community is reading? We sifted through millions of papers viewed in Pubget to share with you the top read papers of the month (according the Pubget users).
Wendy Middlemiss, Douglas A Granger… and Laura Nathans
This study examines change in the synchrony between mothers’ and infants’ physiology as 25 infants (11 males; 4 to 10months of age) participate in a 5-day inpatient sleep training program in which they learn to self-settle through extinction of crying responses during the transition to sleep.
Early Hum Dev 88(4):227-32 (2011) PMID 21945361
2. Novel TaPO5−xN2x/3 oxynitrides
Erwan Ray, Franck Tessier and… Bruno Bureau
A series of novel nitrided tantalophosphates has been prepared by nitridation of x-ray amorphous TaPO5 precursors under ammonia flow.
J Alloys Compd 513:530-538 (2012) PMID
3. Executive functioning in high-IQ adults with ADHD.
Antshel KM, Faraone SV, Maglione K and… Biederman J
The objective was to examine the association between psychological tests of executive functioning and functional outcomes among high-IQ adults with attention deficit hyperactivity disorder (ADHD).
Psychol Med 40(11):1909-18 (2010) PMID 20085666
headlines an article in the December 1902 edition of Science.
We here at Pubget pride ourselves with providing the freshest scientific articles and ensuring that you can easily access the articles your institution has subscriptions to but did you know that you can view PDFs of articles from the past two centuries. Take a look at what your library has to offer by searching a specific year or edition of your favorite publication.
Simply go to the advanced search option on the Pubget home page and jump back in time!
By the way, want to read more about the Mastodon fossils found in New York in 1902? Check it out on Pubget!
PMID: 17745473
Pubget is excited to debut our newest version of the Librarian Portal including OCLC WorldCat knowledge base participants. With this update, managing your library’s data is even easier. Here are some new features coming to the portal:
We’ve consolidated the login management pages into one easy to read page.
Get live updates of your login status as well as email notifications when your data has been added to WorldCat knowledge base or if a login has failed.
Action buttons on the logins page allow easy edits, troubleshooting, or deletion.
Hover over any ? to receive more information.
Be on the look out for more site improvements in the coming weeks. As always, we welcome your feedback, suggestions, and questions. Feel free to email us: team(at)pubget(dot)com
Time Magazine captures Einstein’s office, hours after his death.
Check out a previously unreleased lecture by Einstein on Pubget
Attention physicists, you can use math to help defend yourself in court:
After receiving a $400 ticket for allegedly running a stop sign, Dmitri Krioukov invoked the laws of physics to fight the charge. The University of California, San Diego physicist drafted a four-page paper in his defense, arguing that the police officer mistakenly thought he ran a stop sign due to a unique combination of effects.
Read the full article on Pubget: http://t.co/waTrHJRA
(Source: physicscentral.com)
Developer Meeting 2.0 at Pubget.
Our dev team decided to mix things up a bit with a Google+ hangout for their meeting.
In their defense, the meeting space is pretty far away from their desk (10 feet) and we just don’t have enough monocles in the office.
At Pubget we host our code base on GitHub because of its simplicity, reliability, and great web interface. The extent to which we depend on GitHub is far more than as a convenience, but as the backbone of our engineering team.
Consequently, when GitHub doesn’t have all of the features we need to do our work as efficiently as possible, it’s not just an annoyance, but a source of friction for the entire organization. To grease the wheels of our daily workflow, we’ve begun building a suite of “GitHub Extras” in the form of a Chrome Extension (we’ve also used the API to add tags when we deploy!). Our focus thus far has been on the Issues tool provided by the web interface, upon which we have now added the ability to upload attachments or include a screenshot from any open tab.
What does this mean for our organization? When our product team completes a new feature spec, it’s a simple one-click to upload the Word doc to a new issue for the dev team. While testing internally and a page renders incorrectly on Internet Explorer, it’s a two-second task for the QA team to grab a snapshot of the offending site and create an issue for it.
As we say, “time saved is time spent coding,” and we love to code!
Download the extension here.
Learn more about our dev team workflow here.
