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What's Hot in Science- Top papers from September

Tue, 30 Oct 2012 15:30:47 -0400

Comparative dosimetry of volumetric modulated arc therapy and limited-angle static intensity-modulated radiation therapy for early-stage larynx cancer.
Adam C Riegel, Jeffrey Antone and David L Schwartz
The objective was to compare relative carotid and normal tissue sparing using volumetric-modulated arc therapy (VMAT) or intensity-modulated radiation therapy (IMRT) for early-stage larynx cancer.
Med Dosim [Epub ahead of print] 2012 PMID 22901745
Tumor heterogeneity: mechanisms and bases for a reliable application of molecular marker design.
Salvador J Diaz-Cano
Tumor heterogeneity is a confusing finding in the assessment of neoplasms, potentially resulting in inaccurate diagnostic, prognostic and predictive tests.
Int J Mol Sci 13(2):1951-2011 (2012) PMID 22408433
The impact of gender and parenthood on physicians’ careers—professional and personal situation seven years after graduation.
Barbara B Buddeberg-Fischer, Martina M Stamm and… Richard R Klaghofer
Female physicians, especially those with children, have lower rates of employment and show lower values in terms of career success and career support experiences than male physicians.
BMC Health Serv Res 10:40 (2010) PMID 20167075
Cryopreservation of protocorm-like bodies of the hybrid orchid Bratonia (Miltonia flavescens × Brassia longissima).
Elena Popova, Nikolai Bukhov, Haeng-Hoon Kim
In this study, cryopreservation of Bratonia (Miltonia flavescens (Lindl.) Lindl. × Brassia longissima (Reichb.) Nash), a hybrid tropical orchid, was achieved using protocorm-like bodies (PLBs) multiplied in vitro.
Cryo Letters 31(5):426-37 (2010) PMID 21042657
Reply from Authors re: Ricarda M. Bauer. Female Slings: Where Do We Stand?
Mohamed M Abdel-Fattah
NO ABSTRACT.
Eur Urol 625:853-4 (2012) PMID 22771269
Api88 is a novel antibacterial designer Peptide to treat systemic infections with multidrug-resistant gram-negative pathogens.
Patricia P Czihal, Daniel D Knappe and… Ralf R Hoffmann
We have optimized the sequence to treat systemic infections with the most threatening human pathogens, such as Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii.
ACS Chem Biol 7(7):1281-91 (2012) PMID 22594381
New reaction model for o-o bond formation and o(2) evolution catalyzed by dinuclear manganese complex.
Makoto M Hatakeyama, Hiroya H Nakata and… Shinichiro S Nakamura
We considered the Mn2 complex neutralized by three counterions. Structure optimization made the coordinated OCl- withdraw a H+ from water ligand and produces the reaction space for H2O2 formation with the deprotonated OH- ligand.
J Phys Chem A 116(26):7089-97 (2012) PMID 22672069
Intact-protein-based high-resolution three-dimensional quantitative analysis system for proteome profiling of biological fluids.
Hong Wang, Shawn G Clouthier and… Samir M Hanash
We have implemented an orthogonal three-dimensional intact-protein analysis system (IPAS), coupled with protein tagging and immunodepletion of abundant proteins, to quantitatively profile the human plasma proteome.
Mol Cell Proteomics 4(5):618-25 (2005) PMID 15703445
The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica.
Nicole M Sumracki, Mark R Hutchinson and… Paul Rolan
Patients with unilateral sciatica have heightened responses to intradermal capsaicin compared to pain-free volunteers. No studies have investigated whether this pain model can screen for novel anti-neuropathic agents in patients with pre-existing neuropathic pain syndromes. br /> PLoS ONE7(6):e38525 (2012) PMID 22685578
The use of NICOM (Bioreactance) and Carotid Doppler to determine volume responsiveness and blood flow redistribution following passive leg raising in hemodynamically unstable patients.
Paul E Marik, Alex Levitov, Lois Andrews
In addition, our study suggests that changes in carotid Doppler blood flow following a PLR maneuver may serve as a useful adjunctive method.
Chest [Epub ahead of print] (2012) PMID 22910834
Hippocampal-cortical interactions and the dynamics of memory trace reactivation.
C Daniela Schwindel and Bruce L McNaughton
It is believed that, during slow-wave sleep, the brain reorganizes its connectivity matrix so as to store new information optimally.
Prog Brain Res 19315 (2011) PMID 21854962
The effects of precision, haematocrit, pH and oxygen tension on point-of-care glucose measurement in critically ill patients: a prospective study.
Peter James Watkinson, Vicki Suzanne Barber and… John Duncan Young
A prospective 206 intensive care patient study was carried out. Arterial glucose concentrations were measured in duplicate using three point-of-care instruments (MediSense Precision PCχ, HemoCue DM and Radiometer 700), a central laboratory instrument (Siemens ADVIA), and in whole blood and plasma using the Yellow Springs Instruments 2300 instrument.
Clin Biochem 49144-51 (2012) PMID 22349553
Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment.
Ye Chen, Rodrigo Jacamo and… Michael Andreeff
We describe the development of extramedullary bone and bone marrow using human mesenchymal stromal cells and endothelial colony-forming cells implanted subcutaneously into immunodeficient mice.
Blood 119(21):4971-80 (2012) PMID 22490334
Glass shape influences consumption rate for alcoholic beverages.
Angela S Attwood, Nicholas E Scott-Samuel, Marcus R Munafò
This was an experimental design with beverage (lager, soft drink), glass (straight, curved) and quantity (6 fl oz, 12 fl oz) as between-subjects factors.
PLoS ONE 7(8):e43007 (2012) PMID 22912776
Detecting the immune system response of a 500 year-old Inca mummy.
Angelique Corthals, Antonius Koller and… Liliana M Dávalos
We report the first use of shotgun proteomics to detect the protein expression profile of buccal swabs and cloth samples from two 500-year-old Andean mummies.
PLoS ONE 7(7):e41244 (2012) PMID 22848450

Neuroscience Report: Suggested Reading

Mon, 24 Sep 2012 17:09:00 -0400

Want a PDF of the report. Download it here.

Who should read the report:

This report is intended for anyone interested in advancements in neuroscience, and anyone attending Neuroscience 2012, the Society for Neuroscience’s annual conference.

About this report:

This report highlights 11 papers that represent some of the latest discoveries in the field of neuroscience. Further, each paper is authored by one of the speakers of the Special Lectures at Neuroscience 2012. We chose the paper for its relevance to the topic of the special lecture. To further explore the topic within the neuroscience discipline, we provide two sets of related papers. One set is based on consumption (reading habits of millions of users) and the other set is based on other research the author has published. Our goal is to provide a collection of research papers that represent some of the most exciting new developments in the field of neuroscience.

About the selection and process:

We used the Neuroscience 2012 Special Lectures’ topics and authors as an indicator of interesting and influential research in neuroscience. There are 11 speakers presenting special lectures, across 7 different themes. Our report is organized by author and highlights a recent paper they’ve published on a topic similar to their special lecture topic. Each highlighted paper references the special lecture title and theme. The paper’s title hyperlinks to the paper, via pubget.com. In addition to identifying interesting and influential neuroscience papers, we wanted to identify related papers. We did that in two ways. First, we used data provided via Thomson Reuters Web of Science^® to predict related papers based on reading habits. These papers are hyperlinked via pubget.com. Then we used Pubget’s author database to identify other papers that the author has published. These papers are also hyperlinked via pubget.com.

1. Author: Yves-Alain Barde, MD

Special Lecture: Neurotrophin Signaling: A New Perspective
Special Lecture Theme: Development

Vincent V Bischoff, Vassiliki V Nikoletopoulou and Yves-Alain YA Barde

No abstract.

Med Sci (Paris) 27(2):119-21 (2011) PMID 21382315

Other papers by Yves-Alain Barde, MD

Related papers

2. Author: Gina Turrigiano, PhD

Special Lecture: The Self-Tuning Neuron: Keeping Your Brain in Balance
Special Lecture Theme: Neural Excitability, Synapses, and Glia: Cellular Mechanisms

Gina G Turrigiano

Neural circuits must maintain stable function in the face of many plastic challenges, including changes in synapse number and strength, during learning and development.

Cold Spring Harb Perspect Biol 4(1):a005736 (2012) PMID 22086977

Other papers by Gina G Turrigiano

Related papers

3. Author: David D Julius, PhD

Special Lecture: From Peppers to Peppermints: Molecular Insights into Nociception and Pain

Special Lecture Theme: Neural Excitability, Synapses, and Glia: Cellular Mechanisms

Related Paper:

Signaling by sensory receptors.

David D Julius and Jeremy J Nathans.

Sensory systems detect small molecules, mechanical perturbations, or radiation via the activation of receptor proteins and downstream signaling cascades in specialized sensory cells.

Cold Spring Harb Perspect Biol 4(1):a005991 (2012) PMID 22110046

Other papers by David Julius, PhD

Related papers

4. Author: Lennart Mucke, MD

Special Lecture: Alzheimer Mechanisms and Therapeutic Strategies
Special Lecture Theme: Disorders of the Nervous System

Yadong Y Huang and Lennart L Mucke.

There are still no effective treatments to prevent, halt, or reverse Alzheimer’s disease, but research advances over the past three decades could change this gloomy picture. Genetic studies demonstrate that the disease has multiple causes.

Cell 148(6):1204-22 (2012) PMID 22424230

Other papers by Lennart Mucke, MD

Related papers

5. Author: Antonello Bonci, MD

Special Lecture: Synaptic Plasticity and Substance Use Disorders: New Insights from Optogenetic Studies

Special Lecture Theme: Disorders of the Nervous System

Marisela M Morales and Antonello A Bonci.

No abstract.

Nat Med 18(4):504-5 (2012) PMID 22481411

Other papers by Antonello Bonci, MD

Related papers

6. Author: Donata Oertel

Special Lecture:Handling of Acoustic Information by the Cochlear Nuclear Complex

Special Lecture Theme:Sensory and Motor Systems

Matthew J MJ McGinley, M Charles MC Liberman, … Donata D Oertel.

We test the hypothesis that the topographic arrangement of synaptic inputs on dendrites of octopus cells allows octopus cells to compensate the traveling wave delay. We show that in mice the full cochlear traveling wave delay is 1.6 ms.

J Neurosci 32(27):9301-11 (2012) PMID 22764237

Other papers by Donata Oertel, PhD

Related papers

7. Author: Nikos K Logothetis, PhD

Special Lecture:Large-Scale Brain Networks: Principles and Emerging Methodologies.

Special Lecture Theme:Sensory and Motor Systems

Nikos K Logothetis.

The brain can be envisaged as a complex adaptive system. It is characterized by a very high structural complexity and by massive connectivity, both of which change and evolve in response to experience.

Neuroimage (2012) PMID 22248575

Other papers by Nikos K Logothetis, PhD

Related papers

8. Author: Melissa Hines, PhD

Special Lecture: Sexual Differentiation of Human Brain and Behavior

Special Lecture Theme:Integrative Systems: Neuroendocrinology, Neuroimmunology and Homeostatic Challenge

Melissa M Hines.

Both sexual orientation and sex-typical childhood behaviors, such as toy, playmate and activity preferences, show substantial sex differences, as well as substantial variability within each sex.

Front Neuroendocrinol 32(2):170-82 2011 PMID 21333673

Other papers by Melissa M Hines, PhD

Related papers

9. Author: Christian Lüscher, MD

Special Lecture: Drug-Evoked Synaptic Plasticity: A Key to Addiction?

Special Lecture Theme: Cognition and Behavior

Camilla C Bellone and Christian C Lüscher.

We review the experimental evidence for this hypothesis and discuss the implications for circuit function.

Front Mol Neurosci 5():75 (2012) PMID 22715323

Other papers by Christian Lüscher, MD

10. Author: Amy F. Arnsten, PhD

Special Lecture: Going to Hell in a Handbasket: Molecular Weakening of Prefrontal Cortical Regulation During Stress

Special Lecture Theme: Cognition and Behavior

Amy F T AF Arnsten.

The prefrontal cortex (PFC) - the most evolved brain region - subserves our highest-order cognitive abilities. However, it is also the brain region that is most sensitive to the detrimental effects of stress exposure.

Nat Rev Neurosci 10(6):410-22 1 Jun 2009 PMID 19455173

Other papers by Amy F. Arnsten, PhD

Related papers

11. Author: Xiaowei Zhuang, PhD

Special Lecture: Super-Resolution Fluorescence Microscopy and Applications to Neuroscience

Special Lecture Theme: Novel Methods and Technology Development

Eran A EA Mukamel, Hazen H Babcock and Xiaowei X Zhuang.

We present a computational method, referred to as deconvolution-STORM (deconSTORM), which uses iterative image deconvolution in place of single- or multiemitter localization to estimate the sample.

Biophys J 102(10):2391-400 (2012) PMID 22677393

Other papers by Xiaowei Zhuang, PhD

Related papers

Pubget Paper Popularity Report: Top read papers January-June 2012

Thu, 13 Sep 2012 13:44:00 -0400

Most popular papers may indicate shift in scientific research to social issues such as weight control, gender differences and ADHD

What we found: Socially important issues (think any science headline news) are well represented among the most popular papers. These commonly discussed issues, like weight loss, stress, gender differences and ADHD, were all counted among the most popular papers.

Purpose: With half of 2012 behind us, we set out to curate the most popular papers of 2012 (so far) as read on Pubget.com- the search engine for life science PDFs. With this study we’re able to summarize the interest areas of the millions of scientists who use Pubget.com to find the papers they need to advance their research.

Methodology: Pubget is uniquely positioned to represent the popularity of papers, with a broad index and millions of papers viewed every month. Additionally, Pubget receives traffic from a variety of sources, including Google searches, direct visitors and visitors from referring sites, such as CiteULike, Research Blogging and university websites. This mix of traffic provides a suitably random sample of information.

Results: While the primary focus of our index is on the discovery of papers from across biomedicine (e.g., paper results you’d find in PubMed), the Pubget index is broader and includes publishers in other fields. As such, 25 of the top 30 papers are biomedical related research. Another four papers represent the physical sciences and engineering fields. And one result includes a paper from a popular news magazine.

We noticed a few key trends for this collection of papers.

Health: 8 papers are related to health, with 4 of those being related to diet, weight loss or exercise alone.
Psychology rooted topics including DSM Identified mental disorders and stress: 4 papers related to mental stress or mental disorders, such as ADHD or autism.
Other socially significant topics have emerged popular as well, including gender and cultural differences, and introversion versus extroversion.

Additionally, while about one third of papers were published in 2012, we were surprised by the amount of popular papers published prior to this year. However, this need for researchers to continue reading (relatively) older papers does support the common premise that the scientific community “stands on the shoulders of giants.”

Keep reading for the Top 30. The titles are clickable, and will open the paper through Pubget. If you have a subscription through your workplace, you’ll get the full text. Otherwise, you’ll see the metadata and abstract information, with links to the publisher’s website.

The Top 30 Papers read on Pubget.com

1.The impact of gender and parenthood on physicians’ careers - professional and personal situation seven years after graduation.

Barbara Buddeberg-Fischer, Martina Stamm and… Richard Klaghofer

Female physicians, especially those with children, have lower rates of employment and show lower values in terms of career success and career support experiences than male physicians.

BMC Health Serv Res 10(1):40 (2010) PMID 20167075

2. Improving the antidepressant efficacy of transcranial magnetic stimulation: maximizing the number of stimulations and treatment location in treatment-resistant depression.

WM McDonald, Valerie Durkalski and… Mark S George

The objective was to assess the efficacy of increasing the number of fast left repetitive transcranial magnetic stimulations (rTMS) (10 Hz @ 120% of motor threshold (MT) over the left dorsolateral prefrontal cortex (DLPFC)) needed to achieve remission in treatment-resistant depression (TRD).

Depress Anxiety 28(11):973-80 (2011) PMID 21898711

3. Asynchrony of mother-infant hypothalamic-pituitary-adrenal axis activity following extinction of infant crying responses induced during the transition to sleep.

Wendy Middlemiss, Douglas A Granger and… Laura Nathans

This study examines change in the synchrony between mothers’ and infants’ physiology as 25 infants (11 males; 4 to 10months of age) participate in a 5-day inpatient sleep training program in which they learn to self-settle through extinction of crying responses during the transition to sleep.

Early Hum Dev 88(4):227-32 (2011) PMID 21945361

4. The Rubber Hand Illusion Reveals Proprioceptive and Sensorimotor Differences in Autism Spectrum Disorders.

Bryan Paton, Jakob Hohwy, and Peter G Enticott

Autism spectrum disorder (ASD) is characterized by differences in unimodal and multimodal sensory and proprioceptive processing, with complex biases towards local over global processing. Many of these elements are implicated in versions of the rubber hand illusion (RHI), which were therefore studied in high-functioning individuals with ASD and a typically developing control group.

J Autism Dev Disord [Epub ahead of print] (2011) PMID 22189963

5. Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema.

Ming Shan, Xiaoyi Yuan and… Farrah Kheradmand

We have shown that CD1a(+) antigen-presenting cells (APCs) from lungs of patients with emphysema can induce autoreactive T helper 1 (T(H)1) and T(H)17 cells.

Sci Transl Med 4(117):117ra9 (2012) PMID 22261033

6. Executive functioning in high-IQ adults with ADHD.

KM Antshel, SV Faraone and… J J Biederman

The objective was to examine the association between psychological tests of executive functioning and functional outcomes among high-IQ adults with attention deficit hyperactivity disorder (ADHD).

Psychol Med 40(11):1909-18 (2010) PMID 20085666

7. Adaptive All-Pass Filter Achieving Low Peak-to-Average Power Ratio for OFDM Systems.

Eonpyo Hong and Dongsoo Har

This paper introduces a peak-to-average power ratio (PAPR) reduction scheme adopting a single high-order adaptive all-pass filter (AAPF

IEEE Trans Veh Tech 60(1):4029-4034 (2011) DOI: 10.1109/TVT.2011.2167766&nbsp

8. Absence of adipose triglyceride lipase protects from hepatic ER stress.

Claudia Fuchs, Thierry Claudel and… Michael Trauner

We hypothesized that absence of adipose triglyceride lipase (ATGL/PNPLA2) - the main enzyme for intracellular lipolysis, releasing FAs and closest homologue to adiponutrin (PNPLA3) recently implicated in the pathogenesis of NAFLD - protects against hepatic ER stress.

Hepatology 56(1):270-80 (2012) PMID 22271167

9. Novel TaPO5−xN2x/3 oxynitrides.

Erwan Ray, Franck Tessier and… Bruno Bureau

A series of novel nitrided tantalophosphates has been prepared by nitridation of X-ray amorphous TaPO5precursors under ammonia flow.

J Alloys Compd 513:530-538 (2012)

10. The neural substrates associated with inattentional blindness.

Preston Thakral

Whereas the behavioral manifestation of inattentional blindness has been investigated, the neural basis of this phenomenon has remained elusive. In the current study, event-related fMRI was used to identify the neural substrates associated with inattentional blindness.

Conscious Cogn 20(4):1768-75 (2011) PMID 21481608

11. The unfolding story of a redox chaperone.

MP Mayer

Oxidative stress, especially in combination with heat stress, poses a life-threatening challenge to many organisms by causing protein misfolding and aggregation.

Cell 148(5):843-4 (2012) PMID 22385952

12. Relation Between Serum 25-Hydroxyvitamin D and C-Reactive Protein in Asymptomatic Adults (From the Continuous National Health and Nutrition Examination Survey 2001 to 2006).

Muhammad Amer and Rehan Qayyum

The inverse relation between vitamin D supplementation and inflammatory biomarkers among asymptomatic adults is not settled. We hypothesized that the inverse relation is present only at lower levels and disappears at higher serum levels of vitamin D.

Am J Cardiol 109(2):226-230 (2011) PMID 21996139

13. Efficacy of Low-Level Laser Therapy for Body Contouring and Spot Fat Reduction.

Mary K Caruso-Davis, Thomas S Guillot and… Frank L Greenway

Low-level laser therapy (LLLT) is commonly used in medical applications, but scientific studies of its efficacy and the mechanism by which it causes loss of fat from fat cells for body contouring are lacking. This study examined the effectiveness and mechanism by which 635–680 nm LLLT acts as a non-invasive body contouring intervention method.

Obes Surg 21(6):722-729 (2011) PMID 20393809

14. Fatness leads to inactivity, but inactivity does not lead to fatness: a longitudinal study in children (EarlyBird 45)

B S Metcalf, J Hosking and… T J Wilkin

The objective was to establish in children whether inactivity is the cause of fatness or fatness the cause of inactivity. We designed a non-intervention prospective cohort study examining children annually from 7 to 10 years.

Arch Dis Child 96(10):942-947 (2011) PMID 20573741

15. Totally laparoscopic management of choledochal cyst: Roux-en-Y Jejunojejunostomy and wide hepaticojejunostomy with hilar ductoplasty.

N Urushihara, H Fukuzawa and… H Miyake

In this article, we present our experiences with totally laparoscopic surgery comprising excision of the extrahepatic bile duct, Roux-en-Y jejunojejunostomy, and wide hepaticojejunostomy combined with hilar ductoplasty for choledochal cyst.

J Laparoendosc Adv Surg Tech A 21(4):361-6 (2011) PMID 21486149

16. The upside of being an introvert (and why extroverts are overrated).

Bryan Walsh

By some estimates, 30% of all people fall on the introvert end of the temperament spectrum, introverted does not have to mean shy, though there is overlap. Shy people actively seek to avoid social situations, even ones they might want to take part in, because they may be inhibited by fear. Introverts shun social situations because, they simply want to be alone.

Time 179(5):40-5 (2012) PMID 22355877

17. Tumor heterogeneity: mechanisms and bases for a reliable application of molecular marker design.

Salvador J Diaz-Cano

Tumor heterogeneity is a confusing finding in the assessment of neoplasms, potentially resulting in inaccurate diagnostic, prognostic and predictive tests. This tumor heterogeneity is not always a random and unpredictable phenomenon, whose knowledge helps designing better tests.

Int J Mol Sci 13(2):1951-2011 (2012) PMID 22408433

18. Program and abstracts for the 2011 Meeting of the Society for Glycobiology.

M Tony Hollingsworth, Gerald W Hart and… Carlito B Lebrilla,

We have detected the MUC1CT at promoters of over 500 genes, in association with several different transcription factors, and have shown that promoter occupancy can vary under different growth factor conditions.

Glycobiology 21(11):1454-531 (2011) PMID 21994331

19. DEER distance measurements on proteins.

Gunnar G Jeschke

Distance distributions between paramagnetic centers in the range of 1.8 to 6 nm in membrane proteins and up to 10 nm in deuterated soluble proteins can be measured by the DEER technique.

Annu Rev Phys Chem 63:419-46 (2012) PMID 22404592

20. Fifty years after Jacob and Monod: what are the unanswered questions in molecular biology?

Marc W MW Kirschner, Lucy L Shapiro and… Uri U Alon

Tomorrow’s molecular biologists might wish to look to their predecessors, take risks, and defy convention.

Mol Cell 42(4):403-4 (2011) PMID 21748867

21. Round-bale feeder design affects hay waste and economics during horse feeding.

Krishona Martinson, Julia Wilson and… Marcia Hathaway,

The objectives were to compare hay waste, hay intake, and payback of 9 round-bale feeders and a no-feeder control when used during horse feeding.

J Anim Sci 90(3):1047-55 (2011) PMID 21984721

22. Eye tracking based driver fatigue monitoring and warning system.

Hardeep Singh, J S Bhatia, and Jasbir Kaur,

The main idea behind this project is to develop a non-intrusive system which can detect fatigue of the driver and issue a timely warning.

Power Electronics IICPE (2011) DOI: 10.1109/IICPE.2011.5728062

23. A Low-Glycemic Load Diet Reduces Serum C-Reactive Protein and Modestly Increases Adiponectin in Overweight and Obese Adults.

M L Neuhouser, Y Schwarz and… J W Lampe

We conducted a randomized, cross-over feeding study testing low- compared to High-GL diets on biomarkers of inflammation and adiposity in healthy adults.

J Nutr 142(2):369-374 (2012) PMID 22190020

24.Diagnostic and interventional sialendoscopy: A preliminary experience.

MA Bowen, M Tauzin, EA Kluka and… RR Walvekar

To review our preliminary experience with diagnostic and therapeutic sialendoscopy for the management of non-neoplastic disorders of the salivary gland.

Laryngoscope 121(2):299 (2011) PMID 21271577

25. Differences between tight and loose cultures: a 33-nation study. Michele J Gelfand, Jana L Raver and… Susumu Yamaguchi

We illustrate the differences between cultures that are tight (have many strong norms and a low tolerance of deviant behavior) versus loose (have weak social norms and a high tolerance of deviant behavior).

Science 332(6033):1100-4 (2011) PMID 21617077

26. Rotavirus vaccine series completion and adherence to vaccination schedules among infants in managed care in the United States.

Girishanthy Krishnarajah, Elizabeth J Davis and… Ami R Buikema

Our objective was to compare rotavirus vaccine series completion and dosing schedule compliance between cohorts of infants who received these vaccines.

Vaccine 30(24):3717-22 (2012) PMID 22214886

27. A review of developments in electrospinning technology: New opportunities for the design of artificial tissue structures.

Andreas L Szentivanyi, Holger Zernetsch and… Birgit Glasmacher

It is thus the goal of this review to describe the current state of electrospinning process technology with respect to the design of artificial tissue structures.

Int J Artif Organs 34(10):986-97 (2011) PMID 22161282

28. Pedagogical approach to design an e-learning courseware.

Mohamed Hussain Thowfeek and Azizah Jaafar,

This paper tries to explain the importance of amalgamating the pedagogical approaches and e-learning standards in order to develop an appropriate e-learning courseware.

Pattern Analysis and Intelligent Robotics ICPAIR 2:207-210 (2011) DOI: 10.1109/ICPAIR.2011.5976927

29. Neuroscience: In their nurture

Lizzie Buchen

Can epigenetics underlie the enduring effects of a mother’s love?

Nature 467(7312):146-148 (2010) PMID 20829771

30. The burden of diabetes mellitus among US youth: prevalence estimates from the SEARCH for Diabetes in Youth Study.

Angela D Liese and… Desmond E Williams

Our goal was to estimate the prevalence of diabetes mellitus in youth <20 years of age in 2001 in the United States, according to age, gender, race/ethnicity, and diabetes type.

Pediatrics 118(4):1510-8 (2006) PMID 17015542

Standing in the footprints of giants

Wed, 22 Aug 2012 16:18:21 -0400

via EPOD

As NASA’s Goddard Space Flight Center looks to the stars, dinosaur tracker (how cool does that job sound) Ray Stanford and JHU expert David Weishampel discovered and confirmed (respectively) an intact footprint of a Nodosaur, which roamed the earth about 110 million years ago.

“I don’t know what to do”

Wed, 22 Aug 2012 15:22:32 -0400

“I don’t know what to do”

Researchers: Sound familiar? #whatshouldwecallgradschool

Wed, 22 Aug 2012 15:05:46 -0400

Researchers: Sound familiar? #whatshouldwecallgradschool

Icebergs, Fe, Greenland, Antartica and satellites

Fri, 03 Aug 2012 17:26:12 -0400

A stunningly powerful photo captured by NASA’s Terra satellite (via National Geographic) shows an approximately 50 mile iceberg breaking from Greenland. Icebergs breaking and melting has been scientifically documented for a while now. But did you know that studies have also documented that these free-drifting icebergs can be- at least in southern waters- a source of Iron. Intrigued? Check out this paper, this paper or this paper.

So does that mean that the next time we feel a little anemic we could jaunt over to Antartica for some iron-enriched ocean water?

What's Hot in Science- May Popular Papers

Tue, 26 Jun 2012 17:25:18 -0400

Want to know what the global science community is reading? We sifted through millions of papers viewed in Pubget to share with you the top read papers of the month (according the Pubget users).

1. Asynchrony of mother-infant hypothalamic-pituitary-adrenal axis activity following extinction of infant crying responses induced during the transition to sleep.

Wendy Middlemiss, Douglas A Granger… and Laura Nathans

Early Hum Dev 88(4):227-32 (2011) PMID 21945361

2. Novel TaPO5−xN2x/3 oxynitrides

Erwan Ray, Franck Tessier and… Bruno Bureau

A series of novel nitrided tantalophosphates has been prepared by nitridation of x-ray amorphous TaPO5 precursors under ammonia flow.

J Alloys Compd 513:530-538 (2012) PMID

3. Executive functioning in high-IQ adults with ADHD.

Antshel KM, Faraone SV, Maglione K and… Biederman J

The objective was to examine the association between psychological tests of executive functioning and functional outcomes among high-IQ adults with attention deficit hyperactivity disorder (ADHD).

Psychol Med 40(11):1909-18 (2010) PMID 20085666

4. A 38 kg skin-reducing bilateral mastectomy: a unique case

G Borsetti, G Merlino and… M Borsetti

NO ABSTRACT

J Plast Reconstr Aesthet Surg 62(1):133-134 (2009) PMID 18694661

5. Absence of adipose triglyceride lipase protects from hepatic ER stress Claudia Fuchs, Thierry Claudel and… Michael Trauner

Hepatology [Epub ahead of print] (2012) PMID 22271167

6. Are occupational risk factors associated with markers of disease severity in patients with systemic scleroderma?

Frank A FA Wollheim

NO ABSTRACT.

Nat Clin Pract Rheumatol 2(1):12-3 (2006) PMID 16932644

7. Simulation of angiogenesis and cell differentiation in a CaP scaffold subjected to compressive strains using a lattice modeling approach.

Sandino C, Checa S, Prendergast PJ, Lacroix D

The objective of this study was to investigate the effect of the mechanical stimuli and the capillary network formation on cell differentiation within a scaffold of irregular morphology.

Biomaterials 31(8):2446-52 (2010) PMID 19969348

8. Simulation of cell seeding within a 3D porous scaffold: A fluid-particle analysis.

Andy Olivares and Damien Lacroix

This study opens up the field of numerical predictions related to the interactions between biomaterials, cells and dynamics media.

Tissue Eng Part C Methods [Epub ahead of print] (2012) PMID 22372887

9. Surface display of redox enzymes in microbial fuel cells.

Fishilevich S, Amir L, Fridman Y, Aharoni A and Alfonta L

Our constructed biofuel cell displayed higher power outputs and current densities than those observed for unmodified yeast and a much longer time of operation in comparison with a similar cell where the anode is comprised of purified glucose oxidase.

J Am Chem Soc 131(34):12052-3 (2009) PMID 19663383

10. Outward electron transfer by Saccharomyces cerevisiae monitored with a bi-cathodic microbial fuel cell-type activity sensor.

Raphaël Ducommun, Marie-France Favre and… Fabian Fischer

Knowledge about electron transfer through the cell membrane is of importance in amperometric online monitoring of yeast fermentations and for electricity production with microbial fuel cells.

Yeast 27(3):139-48 (2010) PMID 19946948

11. Tumor heterogeneity: mechanisms and bases for a reliable application of molecular marker design.

Salvador J Diaz-Cano

Int J Mol Sci 13(2):1951-2011 (2012) PMID 22408433

12. Comparison of the efficacy of 5% topical spironolactone gel and placebo in the treatment of mild and moderate acne vulgaris: a randomized controlled trial.

Bahare Malek Afzali, Elena E Yaghoobi and… Mohammad Ali Dabbagh

The objective of this study was to evaluate the efficacy of 5% spironolactone gel in the treatment of mild to moderate acne vulgaris.

J Dermatolog Treat 23(1):21-5 (2010) PMID 20964565

13. Against happiness.

Carl C Elliott

NO ABSTRACT.

Med Health Care Philos 10(2):167-71 (2007) PMID 17541729

14. The impact of gender and parenthood on physicians’ careers - professional and personal situation seven years after graduation.

Barbara Buddeberg-Fischer, Martina Stamm and… Richard Klaghofer

The profile of the medical profession is changing in regard to feminization, attitudes towards the profession, and the lifestyle aspirations of young physicians. The issues addressed in this study are the careers of female and male physicians seven years after graduation and the impact of parenthood on career development.

BMC Health Serv Res 10(1):40 (2010) PMID 20167075

15. Factors influencing injury severity score regarding Thai military personnel injured in mass casualty incident April 10, 2010: lessons learned from armed conflict casualties: a retrospective study.

Boonthep N, Intharachat S, Iemsomboon T

The current study aimed to assess factors influencing Injury Severity Score (ISS) regarding Thai military personelle injured in the mass casualty incident (MCI) April 10, 2010.

BMC Emerg Med 12:1 (2012) PMID 22214518

Tree Trunks Found With Mastodon Remains

Wed, 09 May 2012 14:08:00 -0400

headlines an article in the December 1902 edition of Science.

We here at Pubget pride ourselves with providing the freshest scientific articles and ensuring that you can easily access the articles your institution has subscriptions to but did you know that you can view PDFs of articles from the past two centuries. Take a look at what your library has to offer by searching a specific year or edition of your favorite publication.

Simply go to the advanced search option on the Pubget home page and jump back in time!

By the way, want to read more about the Mastodon fossils found in New York in 1902? Check it out on Pubget!

PMID: 17745473

Introducing the New Librarian Portal

Thu, 19 Apr 2012 14:47:00 -0400

Pubget is excited to debut our newest version of the Librarian Portal including OCLC WorldCat knowledge base participants. With this update, managing your library’s data is even easier. Here are some new features coming to the portal:

A new design with a cleaner navigation

We’ve consolidated the login management pages into one easy to read page.

Get live updates of your login status as well as email notifications when your data has been added to WorldCat knowledge base or if a login has failed.

Action buttons on the logins page allow easy edits, troubleshooting, or deletion.

Hover over any ? to receive more information.

Be on the look out for more site improvements in the coming weeks. As always, we welcome your feedback, suggestions, and questions. Feel free to email us: team(at)pubget(dot)com

Time Magazine captures Einstein’s office, hours after his...

Wed, 18 Apr 2012 14:28:00 -0400

Time Magazine captures Einstein’s office, hours after his death.

Check out a previously unreleased lecture by Einstein on Pubget

The Science of a Traffic Ticket

Tue, 17 Apr 2012 14:09:58 -0400

sayouistiti:

Attention physicists, you can use math to help defend yourself in court:

After receiving a $400 ticket for allegedly running a stop sign, Dmitri Krioukov invoked the laws of physics to fight the charge. The University of California, San Diego physicist drafted a four-page paper in his defense, arguing that the police officer mistakenly thought he ran a stop sign due to a unique combination of effects.

Read the full article on Pubget: http://t.co/waTrHJRA

Developer Meeting 2.0 at Pubget. Our dev team decided to mix...

Thu, 12 Apr 2012 12:47:00 -0400

Developer Meeting 2.0 at Pubget.

Our dev team decided to mix things up a bit with a Google+ hangout for their meeting.

In their defense, the meeting space is pretty far away from their desk (10 feet) and we just don’t have enough monocles in the office.

Spotted at MIT

Thu, 26 Jan 2012 00:00:00 -0500

Be on the look out Boston-area schools, QR codes to download Pubget’s new and improved iPad app will be hitting your campus soon.

Just like on Pubget.com, you can quickly search through and instantly access your library’s subscriptions and now take them on the go with your iPad!

Wait a minute, why wait? You’re already on the computer! Click here to get the app now.

Getting more out of GitHub with Pubget’s Chrome Extension

Tue, 20 Dec 2011 00:00:00 -0500

At Pubget we host our code base on GitHub because of its simplicity, reliability, and great web interface. The extent to which we depend on GitHub is far more than as a convenience, but as the backbone of our engineering team.

Consequently, when GitHub doesn’t have all of the features we need to do our work as efficiently as possible, it’s not just an annoyance, but a source of friction for the entire organization. To grease the wheels of our daily workflow, we’ve begun building a suite of “GitHub Extras” in the form of a Chrome Extension (we’ve also used the API to add tags when we deploy!). Our focus thus far has been on the Issues tool provided by the web interface, upon which we have now added the ability to upload attachments or include a screenshot from any open tab.

What does this mean for our organization? When our product team completes a new feature spec, it’s a simple one-click to upload the Word doc to a new issue for the dev team. While testing internally and a page renders incorrectly on Internet Explorer, it’s a two-second task for the QA team to grab a snapshot of the offending site and create an issue for it.

As we say, “time saved is time spent coding,” and we love to code!

Download the extension here.

Learn more about our dev team workflow here.

Pubget's Automated Builds

Tue, 29 Nov 2011 00:00:00 -0500

As a small team, we don’t have the luxury of dedicated release engineers and thus need to automate our build as much as possible. To do this we use git branches, CruiseControl.rb and some nifty shell scripts to keep new code flowing. Coupled with the automation, we also have a weekly build master rotation where one member of the dev team shields the rest from tracking down build failures.

Ok, a picture is worth a thousand words so here’s our code flow (everything green is automated):

Developers will typically workout out of the DEVELOPMENT branch so this is where new code begins flowing through the system. We find that it’s good practice to link submissions to GitHub issues for management & deploy tracking. The changes then get pulled intoSTAGING which is the continuous build branch for automated testing. We like CruiseControl.rb because it’s light weight & low maintenance. If tests fail, the build master is notified and he can track down the right person to fix the failing test in staging. Once the build is green, the qualified code gets pushed to MASTER which is the production branch behind pubget.com. Since the master branch is considered the healthiest, it feeds down into development and any other project branches that may exist. At this point every branch now has that latest code change and the process begins again.

Too many words? Here’s the short flow:

devs submit to development
changes are tested in staging
qualified changes get pushed to master
development & special project branches stay close to shore through master

It’s definitely worth mentioning that when test failures happen in staging, the automation pauses. Nothing is pulled from development into staging and nothing is pushed from staging into master. This ensures that only healthy code makes its way into production and only the developer that broke the build needs to fix staging. Other developers can continue merging changes into development knowing they will be tested once staging is working again.

This process has helped in a bunch of ways:

developers submit code and trust that it will be qualified, deployed & propagated to all branches
developers stay productive even when the build is broken
we have a production branch where we can quickly apply a hotfix if needed

Pubget Sponsors UCSF PhD Movie Series

Thu, 17 Nov 2011 00:00:00 -0500

We here at Pubget know how much serious work is involved in obtaining your PhD but as we have found out humor is just as big of a process! In any case, we’re pumped to be sponsoring UCSF’s PhD film series this Thursday.

With all the time our research friends are saving by searching on Pubget, they can afford to take a well-deserved break from some intense research.

Free pizza and some laughs, what could be better?

Ever wonder what makes it into Pubget?

Wed, 09 Nov 2011 00:00:00 -0500

Well you can read our official stance below, but here’s the short of it.

As the search engine for life science PDFs, we want to index scientific works from journals that have a strong impact on the scientific community. The journals indexed publish papers which represent the advancements in science, and are the foundation of future discoveries. That’s why you’ll find both the latest issues of your favorite life science journals, as well as papers that represent the foundation of scientific thinking.

Here’s our official stance:

Pubget carefully evaluates and selects content which meets the highest standards of scholarly research from varied disciplines and geographic locations. Journals included in Pubget are examined for timeliness, originality and impact of research, and quality of editorial work. Journals included inPubget contain various article formats from literature review to original research and contain mostly unsolicited works and some commissioned works. The journal’s peer review process is stated clearly with an appropriate percentage of accepted manuscripts and require authors to declare ethical concerns and conflicts related to published works. Many journals publish works reporting on nationally or federally funded research and provide a strong contribution to the field.

Journals with articles that are 100% commissioned, contain less than 3 articles per volume, authored works by editorial board members,advertisement connecting articles, or reprints of previously published works are not included in Pubget.

We hope we’re able to strike a balance between covering everything that the scientific research community needs, while maintaining a high quality of search results. In fitting with our goal, we are actively expanding our index to include important research for the life sciences and beyond. Are their journals that you wish we indexed? Tell us in the comments or write to us at team(at)pubget(dot)com.

A view this week from dev central at Pubget and Chief of Technology Ian Connor.

Sun, 30 Oct 2011 00:00:00 -0400

I don’t know how many of you heard the news out of Princeton last week. And no, I’m not talking about its US News ranking (although go Tigers). I’m talking about the news that the university will ask its scientists to publish only in open access journals. The impetus was apparently to make sure faculty can send around copies of papers they publish without fear of running afoul of a publisher’s copyright.

The event is the latest in a trend toward open access that began in earnest several years ago, when the U.S. government mandated that all research paid for by taxpayer dollars—-through grants from the National Institutes of Health, for example—-be available to those taxpayers free of charge. A compromise was struck with publishers, whose business models largely depend on charging for data, whereby papers would still cost money to access for a certain period immediately after publication before being deposited in a free government-run repository thereafter. Prominent universities like Yale and Harvard have also undertaken open-access policies. As a result, some traditionally subscription-only publishers now allow authors to designate that papers be open-access from the outset, for a fee.

As you can imagine, we follow these things rather closely at Pubget, because they have a direct impact on how we get you papers. Pubget is already the fastest way to get you PDFs that are open access (we help you get your subscription PDFs faster, too, if you’re at one of our 400+ institutions). But knowing when a paper’s become open access takes a bit of work—-and not just for us, but for publishers themselves: because traditionally papers have either been subscription or open access from the start, a world in which different papers in the same journal could potentially be either taxes traditional infrastructure that was built from a journal’s eye view, if you will.

At Pubget, we look at things the way you do: paper by paper. We’ve been working directly with publishers to help them realize our common mission: of letting you get the information you need to do amazing things. But meanwhile, what the news out of Princeton really got me thinking was how much I want to thank all of you out there who have been writing us whenever they find open-access papers that have fallen through the cracks. So, thank you for helping us help you do science at speed.

Pubget Meet Up Thanks to everyone that attended and we trust...

Thu, 27 Oct 2011 00:00:00 -0400

Pubget Meet Up

Thanks to everyone that attended and we trust everyone had a good time. We also gathered some really cool informal feedback on our service and hope to make it even better.

Please look out for more of these or if you have a suggestion on where to have our next one, please contact us and let us know.